Fig. 9

Evolutionary events detected from time-based analysis of patients with persistently active JIA. The 50 gene clusters are aligned vertically at each timestamp. a Red lines represent a set of gene modules which merge into a single module at the 4-month time point and persist through the 12 months of the trial. b Purple lines demonstrate a set of modules which split into another set of gene modules at 4 months, and finally merge into one module in the third timestamp