Fig. 1From: A genome-wide approach to link genotype to clinical outcome by utilizing next generation sequencing and gene chip data of 6,697 breast cancer patientsComplex effects of a single mutation. A cornerstone of our model is the leveraged effect of gene regulation network influencing the final consequence of a mutation. Some target genes will be suppressed while others will be amplified resulting in a markedly changed transcriptomic fingerprint for important genesBack to article page