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Table 1 A list of the top 20 most common cancer and non-cancer (based on Cosmic) mutations identified by analyzing 763 breast cancer samples

From: A genome-wide approach to link genotype to clinical outcome by utilizing next generation sequencing and gene chip data of 6,697 breast cancer patients

Cosmic genesa Non-cosmic genes
Gene % of samples w/ mutations Gene % of samples w/ mutations
FRG1B 58.1 NBPF1 78.2
TTC34 36.5 BAGE2 70.6
PIK3CA 34.6 KMT2C 37.9
CROCC 32.9 BAGE5 34.7
RYR2 30.8 TTN 33.6
TP53 28.1 CROCCP2 33.6
HYDIN 28 MUC16 28.4
NBPF14 24.9 ROCK1P1 23.7
CSF2RA 23.9 TPTE2P6 18.5
PTPRN2 23.9 MST1L 15.9
EIF2B5 23.8 HERC2P4 14.3
PCDHGA1 23.4 MST1P2 14.0
SYNE1 23 DDX12P 13.6
SPDYE3 22.9 DPY19L2P1 12.8
HMCN1 21.2 ANKRD20A9P 11.5
DDX11 20.9 MLLT10P1 11.1
GON4L 20.8 TBC1D3P1-DHX40P1 11.1
PKHD1L1 20.8 MROH7-TTC4 11.0
NEB 20.3 AQP7P1 10.8
USH2A 20.2 SDHAP1 10.6
  1. aVersion: COSMICv71
  2. A significance threshold of 0.01 and a minimal AUC of 0.65 are required for each gene to be considered as significant in the ROC analysis, and the threshold for significance in the survival analysis was set at P <0.05 and average HR >1.4. This analysis included all genes (including the established driver genes as well)