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Fig. 4 | Genome Medicine

Fig. 4

From: Transcriptome sequencing reveals thousands of novel long non-coding RNAs in B cell lymphoma

Fig. 4

Integrative analysis reveals potential functions of DLBCL specific novel LncRNAs. a Biological processes GO ontology from GREAT, shows enrichment for various B cell and lymphoma-related pathways based on the nearby genes possibly regulated by the novel lncRNA. b Disease ontology from GREAT also shows lymphoma-specific disease pathways enriched based on gene in proximity to the novel lncRNAs. c Example of some lncRNAs with significant P values (Boniferroni, P value <0.05) which possibly regulate the functional pathways related to CD40- shown here with number of co-expressed protein coding genes for each, the related CD40-functional pathway, the subset of those co-expressed genes present in the pathway gene set. d Example of a significantly positively correlated lncRNA expression with EZH2 expression across DLBCL tumor samples. e Example of significantly negatively correlated lncRNA expression with EZH2 expression across DLBCL tumor samples

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