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Fig. 9 | Genome Medicine

Fig. 9

From: Transcriptome sequencing reveals thousands of novel long non-coding RNAs in B cell lymphoma

Fig. 9

Mutation analysis suggests that mutations in lncRNAs stabilize their structure. a Difference in MFE (in kcal/mol unit) of native novel lncRNA sequences and mutated sequence with novel mutations shows a shift towards positive end of the scale, indicating stabilization of the secondary RNA structure of the lncRNAs by the novel mutations. b As a control, difference in MFE (in kcal/mol unit) of native novel lncRNA sequences and known dbSNP annotated mutations show a shift towards the negative end of the scale, indicating destabilization of the secondary structure by the dbSNP mutations. c Secondary structure of the original sequence of a lncRNA using RNAfold. d Secondary structure of the mutated sequence for lncRNA shown in (c). The slight change in MFE due to the mutations is also projected in the MFE secondary RNA structure, as highlighted

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