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Fig. 2 | Genome Medicine

Fig. 2

From: HOTAIR and its surrogate DNA methylation signature indicate carboplatin resistance in ovarian cancer

Fig. 2

HOTAIR-associated DNA methylation signature predicts survival in carboplatin-treated ovarian cancer patients. a Heatmap of the 67 CpG DNAme signature (gene symbol for PCGTs in red) strongly associated with HOTAIR expression in ovarian cancers. CpG methylation profiles were centred to mean zero and scaled to unit variance. Blue denotes relative high methylation, yellow relative low methylation. b Correlation scores of the 67-CpG HOTAIR DNAme signature with the corresponding DNAme profiles in embryonic stem cells (ESC), reprogrammed MSCs (iPSC; induced pluripotent stem cells), ovarian cancer cell lines (OVC) with and without stable expression of HOTAIR and MSCs harvested at late (more than four passages) or at early passage (fewer than four passages); P = 10−6 comparing all MSCs to combined ESC/iPSC, P = 10−5 comparing all OVC to all MSC. c Kaplan-Meier curves and log rank test P value of carboplatin-treated patients with a high and low DNAme HOTAIR signature score (INNSBRUCK set). d Validation of the DNA methylation HOTAIR signature in an independent large set of carboplatin-treated serous ovarian cancers from TCGA set (n = 316). e Corresponding Kaplan-Meier curve of HOTAIR signature predictions in the non-carboplatin-treated subset of the TCGA set (n = 26). f Validation of the DNA methylation HOTAIR signature in an independent large set of carboplatin-treated ovarian cancers (EUROPE set, n = 121). g Corresponding Kaplan-Meier curve of HOTAIR signature predictions in the non-carboplatin (cisplatin) treated subset (EUROPE set, n = 85), validating the specificity of the signature. HA HOTAIR, OS overall survival

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