HOTAIR and its surrogate DNA methylation signature indicate carboplatin resistance in ovarian cancer

Table 1 Clinicopathological features of patients from the INNSBRUCK data set stratified according to HOTAIR expression

Characteristics		HOTAIR RNA expression
		Negative	Positive	P value^a
		(n = 62)	(n = 72)	P value^a
Age				0.166
≤ 62.7 years (median age)	67	35	32
> 62.7 years (median age)	67	27	40
FIGO stage				0.733
I/II	37	18	19
III/IV	97	44	53
Tumour grade				0.182
I/II	78	33	45
III	51	28	23
Unknown	5	1	4
Histology				0.145
Serous cancer	56	28	28
Mucinous cancer	43	19	24
Endometrioid cancer	24	14	10
Clear cell cancer	6	1	5
Not classifiable ovarian tissue	2	0	2
Fallopian tube cancer	3	0	3
Residual disease after surgery				0.308
No residual disease	46	22	24
Residual disease ≤ 2 cm	36	19	17
Residual disease > 2 cm	45	20	25
Unknown	7	1	6
Chemotherapy				0.453
Not performed	16	6	10
Performed	118	56	62
Health status				0.074
No relapse	56	31	25
Relapse	78	31	47
Survival status				0.023
Alive	39	24	15
Dead	95	38	57

ISSN: 1756-994X