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Fig. 1 | Genome Medicine

Fig. 1

From: Clinical metagenomic identification of Balamuthia mandrillaris encephalitis and assembly of the draft genome: the continuing case for reference genome sequencing

Fig. 1

Sequencing and comparative phylogenetic analysis of the mitochondrial genome of Balamuthia mandrillaris. a Balamuthia mandrillaris 2046 mitochondrial genome. Annotation of the 41,656 bp genome was performed using RNAmmer, tRNAscan-SE, and Glimmer gene predictor, with all ORFs manually verified using BLASTx alignment. b Phylogenetic analysis of seven newly sequenced mitochondrial genomes from different strains of Balamuthia mandrillaris. An outgroup (for example, Acanthamoeba castellani) is not shown given the lack of gene synteny. Branch lengths are drawn proportionally to the number of nucleotide substitutions per position, and support values are shown for each node. c Differences in individual gene features (cox1, 23S rRNA, and rps3), among the 7 mitochondrial genomes, as detailed in the text. The mitochondrial cox1, 23S rRNA / rnl RNA, and rps3 genes are highlighted in boldface

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