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Fig. 3 | Genome Medicine

Fig. 3

From: Longitudinal analysis of the peripheral B cell repertoire reveals unique effects of immunization with a new influenza virus strain

Fig. 3

Vaccination with 08/09 TIV induced a reduction of the clonal and lineage diversity, while 09 MIV induced an increase in the diversity. A rarefaction analysis (a-d) was performed with progressive subsamples of 1,000 reads (axis x), plotted against the average standard error of clonal groups (a-c) and lineages (d-f) for 08/09 TIV (a and d), 09 MIV (b, e), and 14/15 TIV (c, f) vaccination trials. The empty symbols represent the values for day 0 (pre-immune), while the black symbols stand for those for day 7 after vaccination (two-way ANOVA. *P <0.05; **P <0.01; ***P <0.001). Fluctuations above 7,000 reads in pre-immmune are due to insufficient sequencing depth in two individuals (see also Additional file 3)

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Genome Medicine

ISSN: 1756-994X

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