Fig. 6
Somatic hypermutation analysis in response to 08/09 TIV, 09 MIV, and 14/15 TIV. SHM rates (% of mutations in VH region) are shown according to vaccination trial. In the first approach, 670 randomly sampled lineages per individual were selected and plotted (a-c). (a) 08/09 TIV; (b) 09 MIV; and (c) 14/15 TIV. A second sampling approach was used based on selecting the single largest lineage of 250 VH clonotypes (d-f) (Kruskal–Wallis test. Dunn’s correction for multiple testing. **P <0.01, ***P <0.001)