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Table 1 Demographics of HSCT donors and recipients in the discovery and validation cohorts

From: A donor-specific epigenetic classifier for acute graft-versus-host disease severity in hematopoietic stem cell transplantation

  Discovery cohort Validation cohort
(n = 85 pairs) (n = 32 pairs)
  Donors Recipients Donors Recipients
Sex     
 Female 41 27 14 7
 Male 44 58 18 25
Age at transplant (years)     
 Median 48 52 53 55
 Range 14–72 21–66 22–71 23–64
CMV serostatus     
 Positive 38 43 14 11
 Negative 31 32 16 21
 NA 16 10 2 0
Max. acute GVHD     
 Absent 39 15
 Grade I ('mild') 24 3
 Grade II ('mild') 13 5
 Grade III ('severe') 8 7
 Grade IV ('severe') 1 2
Max. chronic GVHD     
 Absent 54 2
 Limited 21 10
 Extensive 9 3
 NA 1 17
Diagnosis     
 Acute lymphoblastic leukemia 1 1
 Acute myeloid leukemia 17 8
 Chronic granulomatous disease 1 0
 Chronic lymphocytic leukemia (CLL) 11 0
 Chronic myeloid leukemia (CML) 0 3
 Chronic myelomonocytic leukemia 1 0
 Hodgkin lymphoma 9 4
 Myelodysplasia (MDS) 2 0
 MDS/CML/CLL 1 0
 Myelofibrosis 0 2
 Myeloproliferative syndromes/MDS 0 2
 Myeloma 3 0
 Non-Hodgkin lymphoma 37 8
 Other 0 4
 NA 2 0
  Sibling pairs Sibling pairs
Sex match (donor/recipient)   
 Male/male 30 14
 Female/female 13 3
 Male/female 14 4
 Female/male 28 11
CMV match (donor/recipient)   
 Negative/negative 18 13
 Positive/positive 25 8
 Negative/positive 13 3
 Positive/negative 13 6
 NA 16 2
  1. Detailed information regarding criteria for study inclusion is provided in the Methods section. Note that the diagnosis ‘Non-Hodgkin lymphoma’ includes various disease subtypes.
  2. CMV cytomegalovirus, NA data not available