Fig. 2
From: Metagenomic cross-talk: the regulatory interplay between immunogenomics and the microbiome
Effects of the innate and adaptive immune system on metagenome composition. Examples of how the innate and adaptive immune system controls microbiome composition via effector mechanisms. NOD2-dependent secretion of anti-microbial peptides is involved in shaping the configuration of the microbiota. NLRP6 controls mucus secretion by goblet cells, thus having an effect on the epithelial-proximal bacterial compartment. Regulatory T cells orchestrate B-cell-mediated IgA secretion. The IgA repertoire, in turn, controls bacterial targeting by the immune system and thus metagenomic composition. IgA immunoglobin A