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Table 2 Top signals from linear regressions on mean weekly dose (MWD)

From: A multi-factorial analysis of response to warfarin in a UK prospective cohort

            MWD (SD) in mg/week
Variant ID Chr. Pos. Locus Localisation Alleles MAF Beta (SD) P HWE Status Hom. minor Het. Hom. major
rs9923231 16 31015190 VKORC1 Upstream T/C 0.362 −0.875 (0.05335) 5.00E-50* 1.00 Genotyped 16.8 (6.89) 25.99 (9.64) 35.04 (13.63)
rs4917639 10 96715525 CYP2C9 (composite) Intronic C/A 0.208 −0.8334 (0.06864) 2.05E-30* 0.57 Genotyped 14.12 (9.05) 23.77 (9.68) 31.78 (12.92)
rs1057910 10 96731043 CYP2C9 (*3) Non-synonymous coding C/A 0.074 −1.146 (0.1094) 1.24E-23* 0.26 Genotyped 7.55 (1.7) 19.08 (7.69) 29.98 (12.66)
rs1799853 10 96692037 CYP2C9 (*2) Non-synonymous coding A/G 0.126 −0.59 (0.09629) 1.65E-09* 0.01 Genotyped 16.5 (16.94) 23.96 (10.68) 30.09 (13.06)
rs2876443 20 16850210 OTOR, PCSK2 Intergenic G/A 0.378 −0.238 (0.04558) 2.48E-07 0.26 Imputed 25 (10.42) 27.78 (12.82) 30.65 (13.2)
5-164557605 5 164557605 U6, AC008415 Intergenic A/C 0.013 0.9499 (0.1873) 5.34E-07 1.00 Imputed NaN (NA) 37.45 (19.54) 28.24 (12.47)
rs950353 23 30173133 MAGEB1 Intronic A/G 0.076 −0.4548 (0.09473) 2.02E-06 0.29 Imputed 25.39 (10.33) 23.97 (10.45) 29.01 (12.98)
rs13188512 5 7557899 ADCY2 Intronic G/T 0.189 0.2819 (0.05896) 2.21E-06 0.09 Imputed 36.74 (17.71) 30.18 (13.36) 27.37 (12.1)
3-86013074 3 86013074 CADM2 Intronic T/G 0.054 −0.4597 (0.09774) 3.19E-06 1.00 Imputed 16.39 (6.74) 25.6 (13.31) 28.87 (12.69)
rs6571686 14 34290990 BAZ1A Downstream T/A 0.483 −0.2052 (0.04463) 5.22E-06 1.00 Imputed 25.26 (11.44) 29.04 (12.38) 30.14 (14.08)
rs10122258 9 13730846 MPDZ, C9orf146 Intergenic A/T 0.255 0.2302 (0.05111) 8.11E-06 0.69 Imputed 34.96 (15.49) 28.61 (12.57) 27.66 (12.38)
rs2141221 7 94390435 PPP1R9A Intronic T/C 0.460 0.2043 (0.04558) 8.95E-06 0.55 Imputed 31.72 (13.09) 28.43 (12.26) 26.12 (13.07)
rs175811 20 15775473 C20orf133 Intronic C/T 0.167 0.2633 (0.05882) 9.12E-06 0.50 Imputed 34.15 (13.5) 30.82 (13.7) 27.38 (12.23)
rs1496244 11 133052895 OPCML, SPATA19 Intergenic G/A 0.348 0.211 (0.04717) 9.27E-06 0.32 Genotyped 29.14 (10.78) 29.42 (13.32) 27.29 (12.62)
4-128288362 4 128288362 Y RNA, INTU Intergenic A/G 0.034 0.5585 (0.1252) 9.80E-06 0.56 Imputed 40.07 (NA) 32.7 (12.4) 28.22 (12.78)
  1. P values marked with an asterisk were obtained from the regression only adjusting for non-genetic factors, while other P values were obtained from a multiple regression after conditioning on rs9923231, rs1799853 and rs1057910. HWE stands for Hardy-Weinberg Equilibrium and gives the P value of observed number of heterozygous versus expected number of heterozygous, for each variant
  2. Het., heterozygous; Hom. major, homozygous for the major allele; Hom. minor, homozygous for the minor allele