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Table 2 Top signals from linear regressions on mean weekly dose (MWD)

From: A multi-factorial analysis of response to warfarin in a UK prospective cohort

           

MWD (SD) in mg/week

Variant ID

Chr.

Pos.

Locus

Localisation

Alleles

MAF

Beta (SD)

P

HWE

Status

Hom. minor

Het.

Hom. major

rs9923231

16

31015190

VKORC1

Upstream

T/C

0.362

−0.875 (0.05335)

5.00E-50*

1.00

Genotyped

16.8 (6.89)

25.99 (9.64)

35.04 (13.63)

rs4917639

10

96715525

CYP2C9 (composite)

Intronic

C/A

0.208

−0.8334 (0.06864)

2.05E-30*

0.57

Genotyped

14.12 (9.05)

23.77 (9.68)

31.78 (12.92)

rs1057910

10

96731043

CYP2C9 (*3)

Non-synonymous coding

C/A

0.074

−1.146 (0.1094)

1.24E-23*

0.26

Genotyped

7.55 (1.7)

19.08 (7.69)

29.98 (12.66)

rs1799853

10

96692037

CYP2C9 (*2)

Non-synonymous coding

A/G

0.126

−0.59 (0.09629)

1.65E-09*

0.01

Genotyped

16.5 (16.94)

23.96 (10.68)

30.09 (13.06)

rs2876443

20

16850210

OTOR, PCSK2

Intergenic

G/A

0.378

−0.238 (0.04558)

2.48E-07

0.26

Imputed

25 (10.42)

27.78 (12.82)

30.65 (13.2)

5-164557605

5

164557605

U6, AC008415

Intergenic

A/C

0.013

0.9499 (0.1873)

5.34E-07

1.00

Imputed

NaN (NA)

37.45 (19.54)

28.24 (12.47)

rs950353

23

30173133

MAGEB1

Intronic

A/G

0.076

−0.4548 (0.09473)

2.02E-06

0.29

Imputed

25.39 (10.33)

23.97 (10.45)

29.01 (12.98)

rs13188512

5

7557899

ADCY2

Intronic

G/T

0.189

0.2819 (0.05896)

2.21E-06

0.09

Imputed

36.74 (17.71)

30.18 (13.36)

27.37 (12.1)

3-86013074

3

86013074

CADM2

Intronic

T/G

0.054

−0.4597 (0.09774)

3.19E-06

1.00

Imputed

16.39 (6.74)

25.6 (13.31)

28.87 (12.69)

rs6571686

14

34290990

BAZ1A

Downstream

T/A

0.483

−0.2052 (0.04463)

5.22E-06

1.00

Imputed

25.26 (11.44)

29.04 (12.38)

30.14 (14.08)

rs10122258

9

13730846

MPDZ, C9orf146

Intergenic

A/T

0.255

0.2302 (0.05111)

8.11E-06

0.69

Imputed

34.96 (15.49)

28.61 (12.57)

27.66 (12.38)

rs2141221

7

94390435

PPP1R9A

Intronic

T/C

0.460

0.2043 (0.04558)

8.95E-06

0.55

Imputed

31.72 (13.09)

28.43 (12.26)

26.12 (13.07)

rs175811

20

15775473

C20orf133

Intronic

C/T

0.167

0.2633 (0.05882)

9.12E-06

0.50

Imputed

34.15 (13.5)

30.82 (13.7)

27.38 (12.23)

rs1496244

11

133052895

OPCML, SPATA19

Intergenic

G/A

0.348

0.211 (0.04717)

9.27E-06

0.32

Genotyped

29.14 (10.78)

29.42 (13.32)

27.29 (12.62)

4-128288362

4

128288362

Y RNA, INTU

Intergenic

A/G

0.034

0.5585 (0.1252)

9.80E-06

0.56

Imputed

40.07 (NA)

32.7 (12.4)

28.22 (12.78)

  1. P values marked with an asterisk were obtained from the regression only adjusting for non-genetic factors, while other P values were obtained from a multiple regression after conditioning on rs9923231, rs1799853 and rs1057910. HWE stands for Hardy-Weinberg Equilibrium and gives the P value of observed number of heterozygous versus expected number of heterozygous, for each variant
  2. Het., heterozygous; Hom. major, homozygous for the major allele; Hom. minor, homozygous for the minor allele