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Table 3 Thrombin signalling pathway as reported by IPA

From: A multi-factorial analysis of response to warfarin in a UK prospective cohort

Gene symbol Entrez gene name dbSNP P value Location Type(s)
ADCY2 Adenylate cyclase 2 (brain) rs13188512 2.22E-06 Plasma membrane Enzyme
PRKCE Protein kinase C, epsilon rs17034610 1.30E-04 Cytoplasm Kinase
ITPR1 Inositol 1,4,5-triphosphate receptor, type 1 rs13082052 1.94E-04 Cytoplasm Ion channel
EGF Epidermal growth factor rs2298978 1.97E-04 Extracellular space Growth factor
ADCY9 Adenylate cyclase 9 rs57119403 3.53E-04 Plasma membrane Enzyme
PLCB1 Phospholipase C, beta 1 (phosphoinositide-specific) rs227885 3.79E-04 Cytoplasm Enzyme
ARHGEF4 Rho guanine nucleotide exchange factor (GEF) 4 rs4322880 3.98E-04 Cytoplasm Other
PLCE1 Phospholipase C, epsilon 1 rs11187789 6.84E-04 Cytoplasm Enzyme
EGFR Epidermal growth factor receptor rs980653 7.14E-04 Plasma membrane Kinase
ARHGEF3 Rho guanine nucleotide exchange factor (GEF) 3 rs28641188 7.42E-04 Cytoplasm Other
PRKCH Protein kinase C, eta rs959729 7.46E-04 Cytoplasm Kinase
MYL9 Myosin, light chain 9, regulatory rs220076 7.80E-04 Cytoplasm Other
  1. Canonical pathway analysis, in IPA, of warfarin MWD multivariate analysis, grouped 12 signals below 10−03 belonging to the thrombin signalling pathway. Gene symbol, gene name as reported in the Entrez database, the dbSNP variant ID, the P value of the aforementioned variant in the multivariate analysis, the location and type of the associated protein are reported here