A multi-factorial analysis of response to warfarin in a UK prospective cohort

Table 3 Thrombin signalling pathway as reported by IPA

Gene symbol	Entrez gene name	dbSNP	P value	Location	Type(s)
ADCY2	Adenylate cyclase 2 (brain)	rs13188512	2.22E-06	Plasma membrane	Enzyme
PRKCE	Protein kinase C, epsilon	rs17034610	1.30E-04	Cytoplasm	Kinase
ITPR1	Inositol 1,4,5-triphosphate receptor, type 1	rs13082052	1.94E-04	Cytoplasm	Ion channel
EGF	Epidermal growth factor	rs2298978	1.97E-04	Extracellular space	Growth factor
ADCY9	Adenylate cyclase 9	rs57119403	3.53E-04	Plasma membrane	Enzyme
PLCB1	Phospholipase C, beta 1 (phosphoinositide-specific)	rs227885	3.79E-04	Cytoplasm	Enzyme
ARHGEF4	Rho guanine nucleotide exchange factor (GEF) 4	rs4322880	3.98E-04	Cytoplasm	Other
PLCE1	Phospholipase C, epsilon 1	rs11187789	6.84E-04	Cytoplasm	Enzyme
EGFR	Epidermal growth factor receptor	rs980653	7.14E-04	Plasma membrane	Kinase
ARHGEF3	Rho guanine nucleotide exchange factor (GEF) 3	rs28641188	7.42E-04	Cytoplasm	Other
PRKCH	Protein kinase C, eta	rs959729	7.46E-04	Cytoplasm	Kinase
MYL9	Myosin, light chain 9, regulatory	rs220076	7.80E-04	Cytoplasm	Other

Canonical pathway analysis, in IPA, of warfarin MWD multivariate analysis, grouped 12 signals below 10⁻⁰³ belonging to the thrombin signalling pathway. Gene symbol, gene name as reported in the Entrez database, the dbSNP variant ID, the P value of the aforementioned variant in the multivariate analysis, the location and type of the associated protein are reported here

ISSN: 1756-994X