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Table 1 Top 25 differentially methylated regions associated with Alzheimer’s disease in the superior temporal gyrus

From: Genome-wide DNA methylation profiling in the superior temporal gyrus reveals epigenetic signatures associated with Alzheimer’s disease

Chr Start, hg18 End, hg18 DMR length Number of CpGs Associated genes DMR P-value DMR state Largest β difference Most significant P valuea CpG IDb
chr22 48870305 48871199 894 13 MOV10L1 4.26E-20 Hyper 0.069 1.19E-06 cg10828284
chr6 33352149 33354467 2318 53 B3GALT4 1.48E-14 Hyper 0.03 0.00141 cg13882090
chr12 88267918 88269805 1887 13 DUSP6 3.94E-11 Hyper 0.045 7.58E-05 cg05769889
chr1 119332644 119334449 1805 18 TBX15 1.27E-10 Hypo 0.039 0.00207 cg03942051
chr6 30202278 30203782 1504 31 intergenic (nearest gene, TRIM40) 1.28E-09 Hyper 0.03 0.00084 cg08548396
chr6 30081535 30083688 2153 53 HLA-J, ZNRD1-AS1 3.65E-09 Hyper 0.05 0.00192 cg05187508
chr1 3181078 3183141 2063 12 PRDM16 6.99E-09 Hypo 0.038 6.17E-05 cg19263228
chr1 43606133 43607345 1212 12 ELOVL1 7.72E-08 Hypo 0.023 0.00037 cg06350161
chr22 44187332 44188708 1376 17 RIBC2, SMC1B 8.38E-08 Hyper 0.037 0.0008 cg22884516
chr19 56178712 56179781 1069 11 KLK7 8.38E-08 Hyper 0.038 0.0003 cg27497839
chr11 5573477 5574985 1508 10 TRIM6, TRIM6-TRIM34 1.64E-07 Hyper 0.098 0.001 cg00375457
chr12 131575796 131576836 1040 30 FBRSL1 1.79E-07 Hyper 0.028 0.00117 cg25694349
chr6 32252644 32254758 2114 39 AGPAT1, RNF5, RNF5P1 1.79E-07 Hypo 0.032 0.00267 cg11043450
chr2 70977195 70981085 3890 32 VAX2 2.83E-07 Hypo 0.021 0.0005 cg03711129
chr6 32225354 32230126c 4611 70 LOC100507547, PPT2, PPT2-EGFL8, PRRT1 3.42E-07 Hyper 0.024 0.00044 cg01111041
chr10 73148990 73149855 865 6 C10orf105, CDH23 4.38E-07 Hypo 0.034 0.00036 cg18668540
chr6 168159909 168161482 1573 15 KIF25 4.91E-07 Hyper 0.063 0.00055 cg03873264
chr5 139207501 139208427 926 8 NRG2 7.06E-07 Hyper 0.035 1.63E-05 cg15992535
chr6 30146232 30147781 1549 40 RNF39 1.33E-06 Hyper 0.046 0.034 cg03293507
chr5 79021180 79021917 737 12 CMYA5 1.48E-06 Hyper 0.03 0.00351 cg23279355
chr13 32120874 32125755 4881 70 TNXB 2.43E-06 Hypo 0.025 0.00034 cg15786918
chr11 20089216 20089500 284 2 NAV2 2.93E-06 Hypo 0.032 1.41E-09 cg12711760
chr6 32912605 32914526 1921 28 TAP2 4.02E-06 Hyper 0.032 0.00039 cg03438552
chr19 9334057 9335129 1072 13 ZNF177, ZNF559-ZNF177 5.40E-06 Hyper 0.019 2.04E-05 cg17283453
chr6 30819377 30821226 1849 44 FLOT1,IER3 5.65E-06 Hyper 0.031 0.00012 cg13137376
  1. a P-value from per CpG linear regression before DMR/sliding-window analysis
  2. bCpG corresponding to most significant P-value in DMR (a)
  3. cDMR encompassing single nucleotide polymorphisms in linkage disequilibrium with Alzheimer’s disease genome-wide association study loci/brain expression quantitative trait loci (see also Additional file 11: Table S7)
  4. DMR differentially methylated region
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Genome Medicine

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