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Table 1 Top 25 differentially methylated regions associated with Alzheimer’s disease in the superior temporal gyrus

From: Genome-wide DNA methylation profiling in the superior temporal gyrus reveals epigenetic signatures associated with Alzheimer’s disease

Chr

Start, hg18

End, hg18

DMR length

Number of CpGs

Associated genes

DMR P-value

DMR state

Largest β difference

Most significant P valuea

CpG IDb

chr22

48870305

48871199

894

13

MOV10L1

4.26E-20

Hyper

0.069

1.19E-06

cg10828284

chr6

33352149

33354467

2318

53

B3GALT4

1.48E-14

Hyper

0.03

0.00141

cg13882090

chr12

88267918

88269805

1887

13

DUSP6

3.94E-11

Hyper

0.045

7.58E-05

cg05769889

chr1

119332644

119334449

1805

18

TBX15

1.27E-10

Hypo

0.039

0.00207

cg03942051

chr6

30202278

30203782

1504

31

intergenic (nearest gene, TRIM40)

1.28E-09

Hyper

0.03

0.00084

cg08548396

chr6

30081535

30083688

2153

53

HLA-J, ZNRD1-AS1

3.65E-09

Hyper

0.05

0.00192

cg05187508

chr1

3181078

3183141

2063

12

PRDM16

6.99E-09

Hypo

0.038

6.17E-05

cg19263228

chr1

43606133

43607345

1212

12

ELOVL1

7.72E-08

Hypo

0.023

0.00037

cg06350161

chr22

44187332

44188708

1376

17

RIBC2, SMC1B

8.38E-08

Hyper

0.037

0.0008

cg22884516

chr19

56178712

56179781

1069

11

KLK7

8.38E-08

Hyper

0.038

0.0003

cg27497839

chr11

5573477

5574985

1508

10

TRIM6, TRIM6-TRIM34

1.64E-07

Hyper

0.098

0.001

cg00375457

chr12

131575796

131576836

1040

30

FBRSL1

1.79E-07

Hyper

0.028

0.00117

cg25694349

chr6

32252644

32254758

2114

39

AGPAT1, RNF5, RNF5P1

1.79E-07

Hypo

0.032

0.00267

cg11043450

chr2

70977195

70981085

3890

32

VAX2

2.83E-07

Hypo

0.021

0.0005

cg03711129

chr6

32225354

32230126c

4611

70

LOC100507547, PPT2, PPT2-EGFL8, PRRT1

3.42E-07

Hyper

0.024

0.00044

cg01111041

chr10

73148990

73149855

865

6

C10orf105, CDH23

4.38E-07

Hypo

0.034

0.00036

cg18668540

chr6

168159909

168161482

1573

15

KIF25

4.91E-07

Hyper

0.063

0.00055

cg03873264

chr5

139207501

139208427

926

8

NRG2

7.06E-07

Hyper

0.035

1.63E-05

cg15992535

chr6

30146232

30147781

1549

40

RNF39

1.33E-06

Hyper

0.046

0.034

cg03293507

chr5

79021180

79021917

737

12

CMYA5

1.48E-06

Hyper

0.03

0.00351

cg23279355

chr13

32120874

32125755

4881

70

TNXB

2.43E-06

Hypo

0.025

0.00034

cg15786918

chr11

20089216

20089500

284

2

NAV2

2.93E-06

Hypo

0.032

1.41E-09

cg12711760

chr6

32912605

32914526

1921

28

TAP2

4.02E-06

Hyper

0.032

0.00039

cg03438552

chr19

9334057

9335129

1072

13

ZNF177, ZNF559-ZNF177

5.40E-06

Hyper

0.019

2.04E-05

cg17283453

chr6

30819377

30821226

1849

44

FLOT1,IER3

5.65E-06

Hyper

0.031

0.00012

cg13137376

  1. a P-value from per CpG linear regression before DMR/sliding-window analysis
  2. bCpG corresponding to most significant P-value in DMR (a)
  3. cDMR encompassing single nucleotide polymorphisms in linkage disequilibrium with Alzheimer’s disease genome-wide association study loci/brain expression quantitative trait loci (see also Additional file 11: Table S7)
  4. DMR differentially methylated region