Fig. 2

Relative enrichment for somatic mutations of driver TFs domains across approximately 7,000 tumors. a InterPro domains of all driver TFs represented in a space of fraction of variants (with respect to the total in the protein) versus fraction of mutations. The diameter of circles is proportional to the length of the domains (number of amino acids) they represent, and their colors follow the scale for -log(P value) represented at the right of the panel. TP53 and RUNX1 domains are highlighted. (To facilitate visualization of enriched domains the color scale of log P values of enrichment is truncated at 10.) All data included in this figure are provided in Additional file 3: Table S2. b, c Barplot representation of the fraction of mutations (amber) and germline variants (blue) that appear within each domain of TP53 and RUNX1. Each pair of bars correspond to a domain, represented below the graph following the color code presented at the bottom of both graphs. Relative enrichment P values (corresponding to the position of the circles in panel (a) appear at the top of each domain significantly enriched for somatic mutations