Fig. 3

Significant targets of driver TFs in the breast cancer cohort. a Volcano plot with the results of the differential expression analysis. Each circle represents a target gene placed in Mann–Whitney -log(P value) versus log2(fold-change) coordinates. Targets of each TF are represented following the color code represented below the graph. Volcano plots for other tumor types appear in Additional file 1: Figure S3. All data presented in these figures are provided in Additional file 4: Table S6. b-g Distribution of the expression of six illustrated targets of TP53 (b, c), MYC (d, e), and GATA3 (f, g). Each boxplot in the graphs correspond to the expression of the target in samples bearing one type of driver alteration – truncating (T) and missense mutations (M), and deletions (C) in the case of TP53 and GATA3, and amplifications (C) in the case of MYC – any driver alteration (ALL), or no driver alteration (N). Boxplots are only represented for sets of at least five samples. The name of each graph is formed by a concatenation of the name of the target gene, the name of its TF, the Mann–Whitney -log(P value) and the fold-change of its differential expression analysis