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Fig. 4 | Genome Medicine

Fig. 4

From: Circuits of cancer drivers revealed by convergent misregulation of transcription factor targets across tumor types

Fig. 4

Overlap between significant targets of each driver TF across tumor types. a Pairs of tumor types represented in a plane of the Jaccard’s index of the overlap of significant targets versus its significance computed as the Fisher’s -log(q-value). Overlaps between sets of targets of each TF are represented following the color code shown at the bottom of the graph. The diameter of the circles is proportional to the size of the overlapping list of targets. Selected pairs of tumor types with significant overlap of targets of different driver TFs appear at the right of the graph. b Overlap of significant targets of selected TFs between pairs of tumor types where they act as drivers. Heatmaps at the left contain the Jaccard’s index of the overlap between significant targets detected in each tumor type, while heatmaps at the right represent the Fisher’s -log(q-value) of each comparison. Color scales for both magnitudes appear at the bottom of the panel. All data presented in these figures are provided in Additional file 5: Table S7

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