Fig. 5

Circuits of drivers involving TFs. a Driver partner-TF circuits (circles) displayed according to the significance of the overlap of their downregulated targets versus the significance of the overlap of their upregulated targets. The diameter of each circle is proportional to the average size of the overlapping upregulated targets and downregulated targets. The colors of circuits follow the code of their respective TF shown at the bottom of the graph. All data presented in this graph are provided in Additional file 6: Table S8. b-e Examples of the misregulation of targets caused by partner-TF circuits in uterus (b), breast (c), lung (d), and head and neck (e) carcinomas. In each heatmap, target genes are represented as rows and tumor samples are represented as columns. Cells represent the mean-centered values of expression of each target in each tumor sample (color scale below panel a). Upregulated targets appear at the top of the heatmap (purple block), while downregulated targets appear at the bottom (blue block). The uppermost layer of annotations above the columns of the heatmaps signal samples bearing driver mutations of the TF (top row) and the partner (bottom row). The second layer of annotations present the collective degree of alteration of upregulated (top row) and downregulated (bottom row) targets in each tumor samples, determined as the Zscore of the Sample Level Enrichment Analysis (SLEA) of both sets of targets (color scale below panel a). Samples in the heatmap are sorted following the mutual exclusivity pattern of driver alterations in the TF and the partner