Fig. 7

Multilevel principal component analysis of mutational parameters in acute DENV infection. a Single principal component plot of PC1, which represents the number of total, non-synonymous, and synonymous mutations in IGHV segments of controls (red), acute DWS− (DWS− A, green), post-convalescent DWS− (DWS− Pc, dark green), acute DWS+ (DWS+ A, blue), and post-convalescent DWS+ (DWS+ Pc, dark blue). Lower scores for PC1 were observed during the acute phase of DENV infection. DWS− A and DWS− Pc were significantly different (Kruskal–Wallis test, **p < 0.01). b Bi-plot showing clustering of patient samples according to clinical status. DWS− dengue without warning signs; DWS+ dengue with warning signs