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Fig. 9 | Genome Medicine

Fig. 9

From: Lower IgG somatic hypermutation rates during acute dengue virus infection is compatible with a germinal center-independent B cell response

Fig. 9

Proposed model for B cell responses in secondary lymphoid organs during DENV infection. DENV recognition by naïve B cells and during early primary infection occurs in extra-follicular regions and induces a rapid differentiation to Ig-switched antibody-secreting cells (ASCs) secreting unmutated poly/cross-reactive IgG. This pathway may be initiated by DENV low-affinity interactions with B cells using an “innate” IGHV segment such as IGHV1-69 [70] that promotes receptor-mediated endocytosis and TLR7 recognition. Both signals promote T-independent activation and class switch recombination (CSR). Later, the classical germinal center T-dependent response develops, peaking 1–2 weeks after symptoms onset. A secondary infection with a different serotype triggers the same “natural” B cell response derived from naïve B cells that temporally overlaps with a more rapid secondary T-dependent B cell response

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