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Table 2 Enrichment analysis of genes with SNV and IS events. Significant enrichment in classes and pathways assessed using hypergeometric distribution test based on abundance of genes in each category in ACICU, integrated with PanOCT shared clusters report (see text for detail)

From: Genome dynamics of multidrug-resistant Acinetobacter baumannii during infection and treatment

 

SNVs

ISAba1

 

Number of genes in ACICU

Isolate-specific

Patient-restricted

Patient-specific

Isolate-specific

Patient-restricted

Patient-specific

Transporters

282

30***

4

23*

3

0

2

Transcription factors

207

5

2

20**

2

0

4*

Two component regulatory system

26

19***

5***

11***

2

0

4

Lipid A and capsular polysaccharide synthesis

54

7**

2*

5

1

0

0

Iron transport

64

8**

1

4

0

0

1

Motility

31

4*

1

3

1

1

1

Total non-synonymous and non-neutral events used in hypergeometric test calculations

 

123

28

215

21

2

18

  1. * <0.05, ** <0.005, *** <0.0005