Skip to main content
Fig. 4 | Genome Medicine

Fig. 4

From: A roadmap of constitutive NF-κB activity in Hodgkin lymphoma: Dominant roles of p50 and p52 revealed by genome-wide analyses

Fig. 4

Enriched biological processes and genes with significance for HL biology controlled by p50/RelA and p52/RelB. a, b Genes activated (a) or repressed (b) by p50/RelA or p52/RelB in L1236 cells, respectively, and functional enrichment analysis of using Gene Ontology for biological processes (GO) analysis. Top panels: Venn diagrams displaying numbers of total, unique, and overlapping target genes for the two dimer combinations used for GO analysis (solid and stippled arrows, respectively). Direct target genes of p50/RelA and p52/RelB were defined as bound by at least p50 and p52, respectively, by ChIP-sequencing and differentially regulated upon KD of the specific dimers (FDR <0.05), and at least 10 % expression difference between the knockdown and control experiment). See Additional file 10: Table S8 for GO analysis data. c Schematic representation of canonical and non-canonical target genes that are known to be relevant for HL biology. Among both up- and downregulated genes, two functional groups were highly represented in HL literature: (1) cytokines and receptors, and (2) components of NF-κB-subordinated pathways [16, 19, 29, 50]

Back to article page