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Fig. 7 | Genome Medicine

Fig. 7

From: A roadmap of constitutive NF-κB activity in Hodgkin lymphoma: Dominant roles of p50 and p52 revealed by genome-wide analyses

Fig. 7

Canonical and non-canonical NF-κB target genes differentiate primary HL from other lymphoid malignancies. The canonical and non-canonical NF-κB signatures identified in L1236 cells were evaluated using public gene expression data from patient samples (normal and malignant B cells [28]) available in GEO (GSE12453), by comparing their expression in HL samples to the rest. The heat map expression levels are encoded by the base 2 logarithmic scale color bar (right). A total of 123 NF-κB regulated genes were differentially expressed in HL samples and presented concordant expression changes (activation by NF-κB dimers and upregulation in HL samples or repression by NF-κB dimers and downregulation in HL samples). The gene names (left) and lymphoid cell types (top) are indicated. BL, Burkitt’s lymphoma; DLBCL, diffuse large B-cell lymphoma; FL, follicular lymphoma; NLPHL, nodular lymphocyte-predominant HL; TCRBL, T cell-rich B cell lymphoma. Germinal center (GC) B cells are indicated (bottom). See also Additional file 11: Table S9

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