Fig. 5

Quantitative distribution of bacterial proteins. a Number of nonredundant tryptic sequences considered in our MaxQuant search space for human (violet) and oral (green) bacteria. The percentage of shared peptides between human and bacteria among all nonredundant peptides in our search is 0.04 %. b Dynamic range plot of the saliva proteome searched against a combined human and bacterial sequence database. The protein density is color coded and the names of the most abundant proteins are given. c The sum of the top ten peptide intensities per genus serves as a quantitative measure of genus abundance. The 20 most abundant genera are depicted. d PCA of whole genome sequencing (WGS) data from the human microbiome project (HMP) co-analyzed with our saliva proteome data (MSMS). The MS-based proteomics data (MSMS) tightly co-localizes with the mouth sites from the human microbiome project