The influence of a short-term gluten-free diet on the human gut microbiome

Table 3 GFD-induced changes in pathway and module activity

Feature	Coefficient	N.not.0/N	p value	Q-value
KO00380: Tryptophan metabolism	−0.0011	155/155	2.45 × 10⁻⁵	0.002
KO00650: Butyrate metabolism	−0.0014	155/155	2.72 × 10⁻⁵	0.002
KO00071: Fatty acid metabolism	−0.0011	155/155	4.74 × 10⁻⁵	0.002
KO00450: Selenocompound metabolism	0.0009	155/155	9.23 × 10⁻⁵	0.003
KO00630: Glyoxylate and dicarboxylate metabolism	−0.0010	155/155	2.53 × 10⁻⁴	0.007
KO00520 Amino sugar and nucleotide sugar metabolism	0.0009	155/155	2.83 × 10⁻⁴	0.007
M00064: ADP-L-glycero-D-manno-heptose biosynthesis	0.0066	155/155	4.12 × 10⁻⁴	0.023
KO00643: Styrene degradation	−0.0013	155/155	4.29 × 10⁻⁴	0.008
M00077: Chondroitin sulphate degradation Chondroitin sulphate degradation	−0.0037	76/155	5.81 × 10⁻⁴	0.023
KO00760: Nicotinate and nicotinamide metabolism	0.0008	155/155	6.79 × 10⁻⁴	0.012
KO00620: Pyruvate metabolism	−0.0012	155/155	0.002	0.023
KO00253: Tetracycline biosynthesis	−0.0027	155/155	0.002	0.024
KO00471: D-Glutamine and D-glutamate metabolism	0.0012	155/155	0.002	0.024
KO04122: Sulphur relay system	−0.0020	155/155	0.002	0.024
KO00633: Nitrotoluene degradation	−0.0022	155/155	0.002	0.024
KO00072: Synthesis and degradation of ketone bodies	−0.0020	155/155	0.003	0.028
KO00310: Lysine degradation	−0.0007	155/155	0.003	0.031
KO00624: Polycyclic aromatic hydrocarbon degradation	0.0006	155/155	0.005	0.043
KO00561: Glycerolipid metabolism	−0.0012	155/155	0.005	0.043
KO00680: Methane metabolism	−0.0006	155/155	0.006	0.047
KO00550: Peptidoglycan biosynthesis	0.0011	155/155	0.007	0.047

A positive coefficient means more activity of the pathway/module during the habitual diet, while a negative coefficient means less activity of the pathway/module during the habitual diet

ISSN: 1756-994X