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Table 3 GFD-induced changes in pathway and module activity

From: The influence of a short-term gluten-free diet on the human gut microbiome

Feature Coefficient N.not.0/N p value Q-value
KO00380: Tryptophan metabolism −0.0011 155/155 2.45 × 10−5 0.002
KO00650: Butyrate metabolism −0.0014 155/155 2.72 × 10−5 0.002
KO00071: Fatty acid metabolism −0.0011 155/155 4.74 × 10−5 0.002
KO00450: Selenocompound metabolism 0.0009 155/155 9.23 × 10−5 0.003
KO00630: Glyoxylate and dicarboxylate metabolism −0.0010 155/155 2.53 × 10−4 0.007
KO00520 Amino sugar and nucleotide sugar metabolism 0.0009 155/155 2.83 × 10−4 0.007
M00064: ADP-L-glycero-D-manno-heptose biosynthesis 0.0066 155/155 4.12 × 10−4 0.023
KO00643: Styrene degradation −0.0013 155/155 4.29 × 10−4 0.008
M00077: Chondroitin sulphate degradation Chondroitin sulphate degradation −0.0037 76/155 5.81 × 10−4 0.023
KO00760: Nicotinate and nicotinamide metabolism 0.0008 155/155 6.79 × 10−4 0.012
KO00620: Pyruvate metabolism −0.0012 155/155 0.002 0.023
KO00253: Tetracycline biosynthesis −0.0027 155/155 0.002 0.024
KO00471: D-Glutamine and D-glutamate metabolism 0.0012 155/155 0.002 0.024
KO04122: Sulphur relay system −0.0020 155/155 0.002 0.024
KO00633: Nitrotoluene degradation −0.0022 155/155 0.002 0.024
KO00072: Synthesis and degradation of ketone bodies −0.0020 155/155 0.003 0.028
KO00310: Lysine degradation −0.0007 155/155 0.003 0.031
KO00624: Polycyclic aromatic hydrocarbon degradation 0.0006 155/155 0.005 0.043
KO00561: Glycerolipid metabolism −0.0012 155/155 0.005 0.043
KO00680: Methane metabolism −0.0006 155/155 0.006 0.047
KO00550: Peptidoglycan biosynthesis 0.0011 155/155 0.007 0.047
  1. A positive coefficient means more activity of the pathway/module during the habitual diet, while a negative coefficient means less activity of the pathway/module during the habitual diet