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Table 1 Empirical type I error rates for MiSPU and aMiSPU for scenario 1 with a binary outcome

From: An adaptive association test for microbiome data

  MiSPUw(2) MiSPUw() aMiSPUw aMiSPUu aMiSPU
X Z, adjust X 0.052 0.050 0.052 0.049 0.048
X Z, no adjust X 0.051 0.051 0.052 0.049 0.049
XZ, adjust X 0.043 0.038 0.043 0.049 0.040
XZ, no adjust X 0.091 a 0.119 a 0.112 a 0.053 0.088 a
  1. The type I error rate was evaluated for situations in which the covariates were independent of the OTUs (X Z) or correlated with the OTUs (XZ) based on 10,000 simulated data sets at α=0.05
  2. aInflated type I error rates