Fig. 1

Dose escalation of Eμ-Myc Cdkn2a ^-/- cells and resistance to mafosfamide. a Eμ-Myc Cdkn2a ^-/- cells were cultured with increasing doses of mafosfamide. After 10, 18, 23, and 37 days, corresponding to cells cultured in 100, 500, 1000, and 4000 nM of mafosfamide, surviving cells were harvested. b The percentage viability of the resistant cells was measured after 24-h exposure to mafosfamide