Fig. 5
From: Identification of the BRD1 interaction network and its impact on mental disorder risk
Disease risk gene analysis of the BRD1 network. Enrichment for genetic disease risk was investigated for seven BRD1 sub-networks across 12 GWASs comprising eight brain disorders and four disorders that are not considered brain disorders. The bars indicate BRD1 sub-networks in the order: all BRD1-S and BRD1-L PTGs and PPIs (black), BRD1-S PTGs and PPIs, BRD1-S PTGs, BRD1-S PPIs, BRD1-L PTGs and PPIs, BRD1-L PTGs, and BRD1-L PPIs. GWAS from the left are: schizophrenia (scz) [4, 32], attention deficit hyperactivity disorder (adhd) [27, 32], major depressive disorder (mdd) [28, 32], autism spectrum disorder (asd) [32], bipolar disorder (bip) [30, 32], psychiatric cross-disorders (cross) [25, 32], anorexia nervosa (an) [23, 32], Alzheimer’s disease (alz) [24, 37], Crohn’s disease (crohns) [36], rheumatoid arthritis (ra) [29, 33], coronary artery disease (cad) [31, 34], and type 2 diabetes (t2d) [26, 35]. The red line indicates P = 0.05, before correction for the number of GWAS tested. The number of significant loci as well as the number of subjects in each study is noted under each study