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Table 1 Summary of BRD1 PPIs identified by co-IP mass spectrometry

From: Identification of the BRD1 interaction network and its impact on mental disorder risk

Co-IP MS/MS Co-IP strengtha Protein Uniprot ID Gene name Peptide P valueb
BRD1-S 1 BRD1 O95696 Bromodomain-containing protein 1 <1 × 10–10
ZC3H15 Q8WU90 Zinc finger CCCH domain-containing protein 15 <1 × 10–10
DRG1 Q9Y295 Developmentally regulated GTP-binding protein 1 <1 × 10–10
C1QBP Q07021 Complement component 1 Q sub-component-binding protein <1 × 10–10
MYST2 O95251 K(lysine) acetyltransferase 7 <1 × 10–10
SUV420H1 Q4FZB7 Suppressor of variegation 4-20 homolog 1 <1 × 10–10
MEAF6 Q9HAF1 MYST/Esa1-associated factor 6 <1 × 10–10
YWHAE P62258 14-3-3 protein epsilon 5.1 × 10–9
PBRM1 Q86U86 Polybromo-1 2.7 × 10–3
ING4 Q9UNL4 Inhibitor of growth protein 4 4.2 × 10–3
ING5 Q8WYH8 Inhibitor of growth protein 5 1.1 × 10–2
2 NPM1 P06748 Nucleophosmin <1 × 10–10
YWHAZ P63104 14-3-3 protein zeta/delta <1 × 10–10
KPNA1 P52294 Importin subunit alpha-1 <1 × 10–10
KPNA2 P52292 Importin subunit alpha-2 <1 × 10–10
CHD3/CHD4/CHD53 Q14839/Q12873/Q8TDI03 Chromodomain-helicase-DNA-binding protein 3/4/53 <1 × 10–10
YWHAB P31946 14-3-3 protein beta/alpha 1.6 × 10–7
NAP1L4 Q99733 Nucleosome assembly protein 1-like 4 1.6 × 10–7
CLTC Q00610 Clathrin heavy chain 1 2.7 × 10–6
DNMT1 P26358 DNA (cytosine-5)-methyltransferase 1 1.6 × 10–5
LYAR Q9NX58 Cell growth-regulating nucleolar protein 2.1 × 10–5
MRPS14 O60783 28S ribosomal protein S14 5.6 × 10–4
EIF3I Q13347 Eukaryotic translation initiation factor 3 subunit I 5.2 × 10–3
3 PHB2 Q99623 Prohibitin-2 8.4 × 10–7
NSUN2 Q08J23 NOP2/Sun RNA methyltransferase 7.3 × 10–3
BRD1-L 1 BRD1 O95696 Bromodomain-containing protein 1 <1 × 10–10
YWHAE P62258 14-3-3 protein epsilon <1 × 10–10
ZC3H15 Q8WU90 Zinc finger CCCH domain-containing protein 15 <1 × 10–10
DRG1 Q9Y295 Developmentally regulated GTP-binding protein 1 <1 × 10–10
YWHAG P61981 14-3-3 protein gamma <1 × 10–10
MEAF6 Q9HAF1 MYST/Esa1-associated factor 6 8.5 × 10–7
ING5 Q8WYH8 Inhibitor of growth protein 5 9.1 × 10–4
PBRM1 Q86U86 Polybromo-1 1.3 × 10–3
MRPS34 O60783 28S ribosomal protein S14 1.5 × 10–3
ING4 Q9UNL4 Inhibitor of growth protein 4 6.2 × 10–3
QSER1 Q2KHR3 Glutamine and serine-rich protein 1 6.4 × 10–3
2 YWHAZ P63104 14-3-3 protein zeta/delta <1 × 10–10
CLTC Q00610 Clathrin heavy chain 1 9.8 × 10–4
3 H3F3A/HIST1H3/HIST3H3c P84243/P68431/Q16695c Histone H3.3/Histone H3.1/Histone H3.1 tc <1 × 10–10
YWHAH Q04917 14-3-3 protein eta <1 × 10–10
C1QBP Q07021 Complement component 1 Q sub-component-binding protein <1 × 10–10
RPL22L1 Q6P5R6 60S ribosomal protein L22-like <1 × 10–10
  1. aCo-IP strength, 1: co-IPed 3–4 out of four repeated experiments and sample/control enrichment ratio >3 across four control experiments, 2: co-IPed 3–4 times out of four repeated experiments and sample/control enrichment ratio >2 across four control experiments, 3: co-IPed two out of four repeated experiments and sample/control enrichment ratio >3 across four control experiments (for further details see “Methods”)
  2. bCo-IPed proteins were sorted by the peptide P value (MaxQuant software) within each of three settings for co-IP strength
  3. cIdentified peptides were unique to all listed proteins (encoded by more than one genetically related gene)