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Fig. 2 | Genome Medicine

Fig. 2

From: Reconstruction of gene regulatory networks reveals chromatin remodelers and key transcription factors in tumorigenesis

Fig. 2

Association of key transcription factors (TFs) with co-expression pathways. Using the CellNet database of TF–TG associations revealed 142 TFs that were associated with more than 10 % of DEGs. a Expression ratios (relative to BJ) of TFs associated with particular co-expression pathways. b Heat map of hierarchical clustering illustrates the prevalence of corresponding TFs in the regulation of particular co-expression pathways (the color bar corresponds to the − log10(hypergeometric distribution value); red corresponds to high-confidence TF–TG associations, blue to low-confidence associations). c Biological process-based Gene Ontology analysis of clustered groups of TFs associated with particular co-expression pathways (p < 0.05) and prototypic genes

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