Fig. 1
From: Frequent mutations in acetylation and ubiquitination sites suggest novel driver mechanisms of cancer
Importance of cancer mutations in post-translational modification (PTM) sites of acetylation and ubiquitination. a Cancer mutations in protein acetylation sites are significantly more frequent than non-modified protein sequence, while ubiquitination sites show expected mutation rates. PTM sites include central lysine residues and ±7 flanking windows. Comparisons only include proteins with respective PTM sites. b Ubiquitination sites are enriched in protein sequences associated with structured regions, while acetylation sites are evenly distributed among structured and disordered regions. c PTM-associated cancer mutations show greater evolutionary conservation than non-PTM mutations. Disordered and structured protein sequences are compared separately. d PTM-associated cancer mutations are more frequently predicted deleterious by an ensemble of five variant function predictors