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Fig. 3 | Genome Medicine

Fig. 3

From: Development and clinical application of an integrative genomic approach to personalized cancer therapy

Fig. 3

Multiple somatic alterations in components within the same pathways. a Multiple somatic alterations within the APC pathway observed in a colorectal cancer. A schematic of the signaling pathways converging on growth control of colorectal cancer patient P0027 is displayed where mutation and predicted loss of function of tumor suppressors is depicted in red. Several components excluding APC are mutated in the canonical WNT signaling pathway. b Identification of an oncogenic driver in a breast cancer. A schematic of the signaling pathways converging on growth control of breast cancer patient P0040 is displayed where mutation and predicted loss of function of tumor suppressors is depicted in red and activation of oncogenes is depicted in green. Amplification and overexpression of CCND1 is identified through the integrative approach utilized in this study. c An integrative approach identifies the PI3K pathway as potential drug target in a squamous cell carcinoma. A schematic of the signaling pathways converging on growth control of skin squamous cell carcinoma patient P0011 is displayed where mutation and predicted loss of function of tumor suppressors is depicted in red and activation of oncogenes is depicted in green. Multiple tumor suppressors in the PI3K-AKT pathway have mutations that predict loss of function (INPP5D and INPPL1). Additionally, PI3K is mutated, suggesting PI3K-AKT pathway as a possible drug target

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