Development and clinical application of an integrative genomic approach to personalized cancer therapy

Table 3 Summary of genetic alterations in 19 cases of colorectal cancer. Somatic mutations or CNA for the listed genes are shown. Blank indicates wild-type

Patient ID	APC	KRAS	NRAS	BRAF	PIK3CA	PTEN	EGFR	TP53
P0004	p.E763*	p.G12V			p.E545K, p.M1043I
P0005	p.R554*	p.G12S						p.R273H
P0008				p.V600E
P0009	p.E1309fs*4						Gain	p.P151S
P0016		p.G12V			p.E545K			p.R248Q
P0018	p.E1309*, p.V1377fs	p.G13D						p.G245S
P0019	p.R232, p.R1114							p.R333fs*12
P0020	p.T683P, p.R876, p.E1577	p.G13D						p.F270I
P0022	p.T1493fs*14							p.R248Q
P0024	p.E955*	p.N116H,p.Q61P						p.S183*
P0025	p.I606fs, p.R1450*		p.Q61R					p.R273C
P0027						Possible loss		Mutation in donor splice site
P0028	Splice site donor, p.Q1067*							p.R282W
P0031	p.E1097, p.E1397	p.G12D						p.G245S
P0033	p.E1306*	p.G13D						p.R273C
P0034	p.E1322*	p.G12C						p.Y220C
P0037	p.R232*			p.V600E		Splice site acceptor
P0043	p.F1354fs, p.S1400*	p.G13D						p.C176F
P0046	p.R876*		p.G12D					p.S127F
Frequency	0.89	0.53	0.11	0.11	0.11	0.11	0.05	0.84

ISSN: 1756-994X