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Table 3 Summary of genetic alterations in 19 cases of colorectal cancer. Somatic mutations or CNA for the listed genes are shown. Blank indicates wild-type

From: Development and clinical application of an integrative genomic approach to personalized cancer therapy

Patient ID APC KRAS NRAS BRAF PIK3CA PTEN EGFR TP53
P0004 p.E763* p.G12V    p.E545K, p.M1043I    
P0005 p.R554* p.G12S       p.R273H
P0008     p.V600E     
P0009 p.E1309fs*4       Gain p.P151S
P0016   p.G12V    p.E545K    p.R248Q
P0018 p.E1309*, p.V1377fs p.G13D       p.G245S
P0019 p.R232*, p.R1114*        p.R333fs*12
P0020 p.T683P, p.R876*, p.E1577* p.G13D       p.F270I
P0022 p.T1493fs*14        p.R248Q
P0024 p.E955* p.N116H,p.Q61P       p.S183*
P0025 p.I606fs, p.R1450*   p.Q61R      p.R273C
P0027       Possible loss   Mutation in donor splice site
P0028 Splice site donor, p.Q1067*        p.R282W
P0031 p.E1097*, p.E1397* p.G12D       p.G245S
P0033 p.E1306* p.G13D       p.R273C
P0034 p.E1322* p.G12C       p.Y220C
P0037 p.R232*    p.V600E   Splice site acceptor   
P0043 p.F1354fs, p.S1400* p.G13D       p.C176F
P0046 p.R876*   p.G12D      p.S127F
Frequency 0.89 0.53 0.11 0.11 0.11 0.11 0.05 0.84