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Table 4 Summary of genetic alterations in seven cases of breast cancer

From: Development and clinical application of an integrative genomic approach to personalized cancer therapy

Patient ID RNA-Seq ER mRNA HER2 mRNA PIK3CA CCND1 TP53 MAP3K1 MAP2K4 PTEN AKT1 AKT3 Other
P0002 Available High Low p.E545K Amplified   p.F1462V      
P0006 Available High Low p.E542K         
P0007 Not performed NA NA    p.R213fs       CDK1 amplification, RASA1 loss
P0013 Available Low Low    p.R110P       
P0030 Not performed NA NA    p.Y220C       NRAS amplification
P0040 Available High Low   Amplified    p.W95*     
P0042 Not performed NA NA    p.L194R       NF1 mutation
  1. Somatic mutations or CNA for the listed genes are shown. Blank indicates wild-type. ER and HER2 mRNA level derived from RNA-Seq data are summarized as high or low using the TCGA breast cancer RNA-Seq data as references