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Table 4 Summary of genetic alterations in seven cases of breast cancer

From: Development and clinical application of an integrative genomic approach to personalized cancer therapy

Patient ID

RNA-Seq

ER mRNA

HER2 mRNA

PIK3CA

CCND1

TP53

MAP3K1

MAP2K4

PTEN

AKT1

AKT3

Other

P0002

Available

High

Low

p.E545K

Amplified

 

p.F1462V

     

P0006

Available

High

Low

p.E542K

        

P0007

Not performed

NA

NA

  

p.R213fs

     

CDK1 amplification, RASA1 loss

P0013

Available

Low

Low

  

p.R110P

      

P0030

Not performed

NA

NA

  

p.Y220C

     

NRAS amplification

P0040

Available

High

Low

 

Amplified

  

p.W95*

    

P0042

Not performed

NA

NA

  

p.L194R

     

NF1 mutation

  1. Somatic mutations or CNA for the listed genes are shown. Blank indicates wild-type. ER and HER2 mRNA level derived from RNA-Seq data are summarized as high or low using the TCGA breast cancer RNA-Seq data as references
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Genome Medicine

ISSN: 1756-994X

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