Fig. 8

miR-342-3p-repressed anti-apoptotic gene network in macrophages. a Relative expression heatmap of selected potential anti-apoptotic miR-342-3p target gene expression in miR-negative control (miR-neg) and miR-342-3p-overexpressing RAW264.7 cells 18 h after miRNA mimic transfection in three independent experiments (significance of repression is indicated after the gene name: *FDR ≤0.1, **FDR ≤0.05, ***FDR ≤0.01). b GeneMANIA-based identification of the miR-342-3p-repressed, anti-apoptotic gene network. c Luciferase activity in HEK293T cells cotransfected with luciferase expression constructs containing WT or mutated (Del) miR-342-3p binding sites of Bcl2l1 and miR-342-3p/miRNA negative-control mimics (n = 6). *P ˂ 0.05, ns. not significant