TY - JOUR AU - Galson, Jacob D. AU - Trück, Johannes AU - Clutterbuck, Elizabeth A. AU - Fowler, Anna AU - Cerundolo, Vincenzo AU - Pollard, Andrew J. AU - Lunter, Gerton AU - Kelly, Dominic F. PY - 2016 DA - 2016/06/16 TI - B-cell repertoire dynamics after sequential hepatitis B vaccination and evidence for cross-reactive B-cell activation JO - Genome Medicine SP - 68 VL - 8 IS - 1 AB - A diverse B-cell repertoire is essential for recognition and response to infectious and vaccine antigens. High-throughput sequencing of B-cell receptor (BCR) genes can now be used to study the B-cell repertoire at great depth and may shed more light on B-cell responses than conventional immunological methods. Here, we use high-throughput BCR sequencing to provide novel insight into B-cell dynamics following a primary course of hepatitis B vaccination. SN - 1756-994X UR - https://doi.org/10.1186/s13073-016-0322-z DO - 10.1186/s13073-016-0322-z ID - Galson2016 ER -