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Fig. 2 | Genome Medicine

Fig. 2

From: B-cell repertoire dynamics after sequential hepatitis B vaccination and evidence for cross-reactive B-cell activation

Fig. 2

Fluctuations in the total repertoire. a Mean percentage of the total repertoire comprising the 50 most frequent clusters at each day (see also Additional file 1: Figure S3). b Mean number of V gene mutations from all sequences in the repertoire. c Mean CDR3 AA sequence length from all sequences in the repertoire. For ac, error bars indicate ± SEM from nine participants. d The percentage of clusters shared by each pair of participants at each visit was determined (nine participants, giving 36 pairings). Shown are the mean values ± SEM of the percentage of clusters shared between each pair. Percent is calculated as (A∩B/size(AB)) × 100. Shared clusters are defined as those which share the same V and J gene segment and cluster center CDR3 nucleotide sequence. All p values were obtained from Mann–Whitney U tests

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