Fig. 5

Kinetics of the vaccine-enriched clusters. The vaccine-enriched clusters were found in each participant and, at each day, the frequencies of these clusters are plotted as a stacked bar chart, centered to the middle of the y-axis. Clusters from each day are then joined using a horizontal stream to illustrate how the frequency of the clusters changes over time. The width of the stream represents the frequency of the cluster at that time and the color of the stream represents the first visit at which sequences from the cluster can be found. The top four plots are from participants who were given the accelerated vaccine schedule and the bottom five plots are from participants who were given the conventional vaccine schedule. Dotted vertical lines highlight the day 7 post-vaccination visits. *The day 168 blood sample was missing from this participant but the vaccine was still given on this day. See also Additional file 1: Figure S4 and Table S3 for kinetics of vaccine-enriched clusters as defined by similarity to previously publish HBsAg-specific monoclonal antibody sequences