Skip to main content
Fig. 7 | Genome Medicine

Fig. 7

From: B-cell repertoire dynamics after sequential hepatitis B vaccination and evidence for cross-reactive B-cell activation

Fig. 7

Properties of vaccine-enriched clusters present at each of the three day 7 post-vaccination visits. At each visit, the clusters were split according to the visit when they were first identified. a Difference in number of V gene mutations of vaccine-enriched clusters at each visit. b, c Lineage trees were constructed where these clusters contained at least 25 sequences and the trunk length (b) and sequence diversity within the lineage (c) calculated for each. Mean values ± SEM are shown and the number of clusters is indicated at the bottom of each bar. Comparisons were performed using a Mann–Whitney U test. See also Additional file 1: Figure S5. d Difference in selection strength in the CDR and framework regions (FWR) of the clusters identified at different visits. Mean values ± 95 % confidence interval are shown

Back to article page