Fig. 1
From: Making sense of big data in health research: Towards an EU action plan
Making sense of complex data and overcoming the hairball syndrome using systems biology algorithms and visualization tools. a Visualization of the topology of clinical data from the U-BIOPRED consortium adult severe asthma cohorts (courtesy of Ratko Djukanovic, University of Southampton, UK and Peter Sterk, Amsterdam Medical Center, The Netherlands) [126] using Topology Data Analysis from Ayasdi [127, 128]. b Network obtained though integration of genome, transcriptome, and proteome data from the SysCLAD consortium lung transplantation cohorts (courtesy of Johann Pellet, EISBM, France) [129, 130] using Ingenuity® Variant Analysis [131]. c Typical static representation of a molecular pathway in Thomson Reuters GeneGo MetaCore™ [132]. d An example of a detailed representation of biochemical reactions in the LCSB Parkinson’s molecular map [133]. e A cellular-level representation of biological interactions in the EISBM AsthmaMap (courtesy of Alexander Mazein, EISBM, France) [134, 135]. f A network representation of data and statements developed as part of a biocentric knowledge base within the eTRIKS consortium (courtesy of Mansoor Saqi and Irina Balaur, EISBM, France) [67]