Skip to main content

Table 1 Frequency spectrum of hTERT promoter mutations across diverse cancer types

From: Roles of telomeres and telomerase in cancer, and advances in telomerase-targeted therapies

Cancer type

Mutation frequency (%)

Reference

Bladder carcinoma

47–85

[100]

Renal pelvic carcinoma

60–64

[101]

Urothelial carcinoma

47

[102]

Hepatocellular carcinoma

24–59

[6, 103]

Melanoma

67–85

[3]

Skin basal cell carcinoma

39–74

[104]

Thyroid cancer (papillary and poorly differentiated carcinomas)

50–52

[105]

Myxoid liposarcoma

74–79

[106]

Glioblastoma

28–84

[6, 48]

Medulloblastoma

19–42

[107]

Oligoastrocytoma

Oligodendroglioma

25–53

72

[6, 107]

[44]

Breast cancer, colorectal cancer, medullary thyroid carcinoma, ovarian cancer, esophageal adenocarcinoma, acute myeloid leukemia, chronic lymphoid leukemia, pancreatic cancer, prostate cancer, testicular carcinoma, uterine cervix cancer

0–5

[48, 104]