From: Roles of telomeres and telomerase in cancer, and advances in telomerase-targeted therapies
Identifier code/phase | Indication | Objective | Start/completion date | Results | Sponsor/reference |
---|---|---|---|---|---|
NCT00510133/GRNVAC1 phase II | Acute myelogenous leukemia | Efficacy | July 2007/August 2014 | GRNVAC1 was found to be safe and well tolerated. Positive immune responses in 55Â % of patients. Toxicity: thrombocytopenia. | Asterias Biotherapeutics (http://asteriasbiotherapeutics.com/pipeline/ast-vac1/) |
NCT01579188/GV1001 phase III | Non-small-cell lung cancer | Efficacy | May 2012/May 2016 | Ongoing. | Kael-GemVax |
NCT00425360/GV1001 phase III | Metastatic pancreatic cancer | Efficacy in combination with chemotherapy | September 2006/ March 2013 | Adding GV1001 vaccination to chemotherapy did not improve overall survival. | [108] |
NCT01935154/Vx001 phase II | Non-small-cell lung cancer | Efficacy | August 2012/ December 2016 | Active. | Vaxon Biotech (http://www.clinicaltrials.gov) |