Fig. 4

eQTLs are independent of total magnitude of gene expression and not preferentially associated with active enhancer marks. a Expression of TNFSF and TNFRSF members was measured by the NanoString nCounter analysis system. Each point represents average expression over eight or more individuals, including healthy controls and individuals with IBD. Genes are listed left to right in order of decreasing number of cell types in which an eQTL was detected. b Average H3K27ac ChIP-seq or input DNA sequencing counts per million intersecting TNFSF-related eQTL SNPs in the same cell type are plotted. c Average H3K27ac ChIP-seq counts per million intersecting eQTL SNPs in the same cell type are compared with a random distribution of intersections created by selecting the same number of SNPs from the cis genomic regions used for eQTL search. Error bars represent the standard deviation of 10,000 iterations of random selection. d eQTL chi-squared scores from the strongest eQTL SNP for each TNFSF-related gene (regardless of whether the association passed our eQTL significance threshold) are compared with H3K27ac ChIP-seq or input DNA sequencing counts per million at the same SNPs. Spearman correlation coefficient (rho) and correlation p values (p) are indicated for H3K27ac ChIP-seq counts per million versus eQTL score