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Fig. 5 | Genome Medicine

Fig. 5

From: Targeted genomic analysis reveals widespread autoimmune disease association with regulatory variants in the TNF superfamily cytokine signalling network

Fig. 5

Immune-mediated disease risk alleles can either increase or decrease TNFSF-related gene expression. a Autoimmune and autoinflammatory disease GWAS hits tagged by TNFSF-related cis-eQTLs were identified and the directions of effect of the risk alleles on expression are plotted. Disease-associated SNPs that are eQTL SNPs in multiple cell types or are associated with multiple diseases are counted only once. “n” indicates the number of SNPs in each slice of the pie. b TNFSF14 expression is plotted against MS-associated SNP rs1077667 genotype. Allele A is protective. P values are provided for eQTLs with FDR < 0.1; NS indicates not significant. c Disease-associated eQTL SNPs depicted in a are plotted by eQTL cell type and disease association. Effect directions are coloured as in a. SNPs associated with more than one disease are plotted once per disease

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Genome Medicine

ISSN: 1756-994X

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