TY - STD TI - Hindorff LA, Sethupathy P, Junkins HA, Ramos EM, Mehta JP, Collins FS, Manolio TA. Potential etiologic and functional implications of genome-wide association loci for human diseases and traits. Proc Natl Acad Sci U S A. 2009;106(23):9362–7. ID - ref1 ER - TY - STD TI - Welter D, MacArthur J, Morales J, Burdett T, Hall P, Junkins H, Klemm A, Flicek P, Manolio T, Hindorff L et al. The NHGRI GWAS Catalog, a curated resource of SNP-trait associations. Nucleic Acids Res. 2014;42(Database issue):D1001–1006. ID - ref2 ER - TY - JOUR AU - Visscher Peter, M. AU - Brown Matthew, A. AU - McCarthy Mark, I. AU - Yang, J. PY - 2012 DA - 2012// TI - Five years of GWAS discovery JO - Am J Hum Genet VL - 90 UR - https://doi.org/10.1016/j.ajhg.2011.11.029 DO - 10.1016/j.ajhg.2011.11.029 ID - Visscher Peter2012 ER - TY - JOUR AU - Westra, H. J. AU - Franke, L. PY - 2014 DA - 2014// TI - From genome to function by studying eQTLs JO - Biochim Biophys Acta VL - 1842 UR - https://doi.org/10.1016/j.bbadis.2014.04.024 DO - 10.1016/j.bbadis.2014.04.024 ID - Westra2014 ER - TY - STD TI - Westra H-J, Peters MJ, Esko T, Yaghootkar H, Schurmann C, Kettunen J, Christiansen MW, Fairfax BP, Schramm K, Powell JE et al. Systematic identification of trans eQTLs as putative drivers of known disease associations. Nat Genet. 2013;45(10):1238–43. ID - ref5 ER - TY - JOUR AU - Albert, F. W. AU - Kruglyak, L. PY - 2015 DA - 2015// TI - The role of regulatory variation in complex traits and disease JO - Nat Rev Genet VL - 16 UR - https://doi.org/10.1038/nrg3891 DO - 10.1038/nrg3891 ID - Albert2015 ER - TY - STD TI - Giambartolomei C, Vukcevic D, Schadt EE, Franke L, Hingorani AD, Wallace C, Plagnol V. Bayesian test for colocalisation between pairs of genetic association studies using summary statistics. PLoS Genet. 2014;10(5):e1004383. ID - ref7 ER - TY - STD TI - Gusev A, Ko A, Shi H, Bhatia G, Chung W, Penninx BWJH, Jansen R, de Geus EJC, Boomsma DI, Wright FA et al. Integrative approaches for large-scale transcriptome-wide association studies. Nat Genet. 2016;48(3):245–52. ID - ref8 ER - TY - STD TI - Gamazon ER, Wheeler HE, Shah KP, Mozaffari SV, Aquino-Michaels K, Carroll RJ, Eyler AE, Denny JC, Consortium GT, Nicolae DL et al. A gene-based association method for mapping traits using reference transcriptome data. Nat Genet. 2015;47(9):1091–8. ID - ref9 ER - TY - STD TI - He X, Fuller CK, Song Y, Meng Q, Zhang B, Yang X, Li H. Sherlock: detecting gene-disease associations by matching patterns of expression QTL and GWAS. Am J Hum Genet. 2013;92(5):667–80. ID - ref10 ER - TY - STD TI - Zhu Z, Zhang F, Hu H, Bakshi A, Robinson MR, Powell JE, Montgomery GW, Goddard ME, Wray NR, Visscher PM et al. Integration of summary data from GWAS and eQTL studies predicts complex trait gene targets. Nat Genet. 2016;48:481–7. ID - ref11 ER - TY - STD TI - SMR software tool. http://www.cnsgenomics.com/software/smr/. Accessed 22 July 2016. UR - http://www.cnsgenomics.com/software/smr/ ID - ref12 ER - TY - STD TI - SMR Results Database. http://www.cnsgenomics.com/shiny/SMRdb/. Accessed 22 July 2016. UR - http://www.cnsgenomics.com/shiny/SMRdb/ ID - ref13 ER - TY - JOUR AU - VanderWeele, T. J. AU - Tchetgen Tchetgen, E. J. AU - Cornelis, M. AU - Kraft, P. PY - 2014 DA - 2014// TI - Methodological challenges in mendelian randomization JO - Epidemiology VL - 25 UR - https://doi.org/10.1097/EDE.0000000000000081 DO - 10.1097/EDE.0000000000000081 ID - VanderWeele2014 ER - TY - JOUR AU - Boef, A. G. AU - Dekkers, O. M. AU - Cessie, S. PY - 2015 DA - 2015// TI - Mendelian randomization studies: a review of the approaches used and the quality of reporting JO - Int J Epidemiol VL - 44 UR - https://doi.org/10.1093/ije/dyv071 DO - 10.1093/ije/dyv071 ID - Boef2015 ER - TY - JOUR AU - Lawlor, D. A. AU - Harbord, R. M. AU - Sterne, J. A. AU - Timpson, N. AU - Davey, S. G. PY - 2008 DA - 2008// TI - Mendelian randomization: using genes as instruments for making causal inferences in epidemiology JO - Stat Med VL - 27 UR - https://doi.org/10.1002/sim.3034 DO - 10.1002/sim.3034 ID - Lawlor2008 ER - TY - JOUR AU - Pierce, B. L. AU - Burgess, S. PY - 2013 DA - 2013// TI - Efficient design for Mendelian randomization studies: subsample and 2-sample instrumental variable estimators JO - Am J Epidemiol VL - 178 UR - https://doi.org/10.1093/aje/kwt084 DO - 10.1093/aje/kwt084 ID - Pierce2013 ER - TY - JOUR AU - Inoue, A. AU - Solon, G. PY - 2010 DA - 2010// TI - Two-sample instrumental variables estimators JO - Rev Econ Stat. VL - 92 UR - https://doi.org/10.1162/REST_a_00011 DO - 10.1162/REST_a_00011 ID - Inoue2010 ER - TY - STD TI - Liu JZ, van Sommeren S, Huang H, Ng SC, Alberts R, Takahashi A, Ripke S, Lee JC, Jostins L, Shah T et al. Association analyses identify 38 susceptibility loci for inflammatory bowel disease and highlight shared genetic risk across populations. Nat Genet. 2015;47(9):979–86. ID - ref19 ER - TY - STD TI - Franke A, McGovern DP, Barrett JC, Wang K, Radford-Smith GL, Ahmad T, Lees CW, Balschun T, Lee J, Roberts R et al. Genome-wide meta-analysis increases to 71 the number of confirmed Crohn’s disease susceptibility loci. Nat Genet. 2010;42(12):1118–25. ID - ref20 ER - TY - STD TI - Anderson CA, Boucher G, Lees CW, Franke A, D’Amato M, Taylor KD, Lee JC, Goyette P, Imielinski M, Latiano A et al. Meta-analysis identifies 29 additional ulcerative colitis risk loci, increasing the number of confirmed associations to 47. Nat Genet. 2011;43(3):246–52. ID - ref21 ER - TY - JOUR PY - 2013 DA - 2013// TI - Identification of risk loci with shared effects on five major psychiatric disorders: a genome-wide analysis JO - Lancet. VL - 381 UR - https://doi.org/10.1016/S0140-6736(12)62129-1 DO - 10.1016/S0140-6736(12)62129-1 ID - ref22 ER - TY - STD TI - Lambert J-C, Ibrahim-Verbaas CA, Harold D, Naj AC, Sims R, Bellenguez C, Jun G, DeStefano AL, Bis JC, Beecham GW et al. Meta-analysis of 74,046 individuals identifies 11 new susceptibility loci for Alzheimer’s disease. Nat Genet. 2013;45(12):1452–8. ID - ref23 ER - TY - STD TI - Robinson EB, St Pourcain B, Anttila V, Kosmicki JA, Bulik-Sullivan B, Grove J, Maller J, Samocha KE, Sanders SJ, Ripke S et al. Genetic risk for autism spectrum disorders and neuropsychiatric variation in the general population. Nat Genet. 2016;48:552–5. ID - ref24 ER - TY - STD TI - Sklar P, Ripke S, Scott LJ, Andreassen OA, Cichon S, Craddock N, Edenberg HJ, Nurnberger JI, Rietschel M, Blackwood D et al. Large-scale genome-wide association analysis of bipolar disorder identifies a new susceptibility locus near ODZ4. Nat Genet. 2011;43(10):977–83. ID - ref25 ER - TY - STD TI - Ripke S, Wray NR, Lewis CM, Hamilton SP, Weissman MM, Breen G, Byrne EM, Blackwood DH, Boomsma DI, Cichon S et al. A mega-analysis of genome-wide association studies for major depressive disorder. Mol Psychiatry. 2013;18(4):497–511. ID - ref26 ER - TY - STD TI - Nikpay M, Goel A, Won HH, Hall LM, Willenborg C, Kanoni S, Saleheen D, Kyriakou T, Nelson CP, Hopewell JC et al. A comprehensive 1,000 Genomes-based genome-wide association meta-analysis of coronary artery disease. Nat Genet. 2015;47(10):1121–30. ID - ref27 ER - TY - JOUR PY - 2011 DA - 2011// TI - Genetic variants in novel pathways influence blood pressure and cardiovascular disease risk JO - Nature. VL - 478 UR - https://doi.org/10.1038/nature10405 DO - 10.1038/nature10405 ID - ref28 ER - TY - JOUR PY - 2013 DA - 2013// TI - Discovery and refinement of loci associated with lipid levels JO - Nat Genet. VL - 45 UR - https://doi.org/10.1038/ng.2797 DO - 10.1038/ng.2797 ID - ref29 ER - TY - STD TI - Morris AP, Voight BF, Teslovich TM, Ferreira T, Segre AV, Steinthorsdottir V, Strawbridge RJ, Khan H, Grallert H, Mahajan A et al. Large-scale association analysis provides insights into the genetic architecture and pathophysiology of type 2 diabetes. Nat Genet. 2012;44(9):981–90. ID - ref30 ER - TY - STD TI - Dupuis J, Langenberg C, Prokopenko I, Saxena R, Soranzo N, Jackson AU, Wheeler E, Glazer NL, Bouatia-Naji N, Gloyn AL et al. New genetic loci implicated in fasting glucose homeostasis and their impact on type 2 diabetes risk. Nat Genet. 2010;42(2):105–16. ID - ref31 ER - TY - JOUR PY - 2010 DA - 2010// TI - Genome-wide meta-analyses identify multiple loci associated with smoking behavior JO - Nat Genet. VL - 42 UR - https://doi.org/10.1038/ng.571 DO - 10.1038/ng.571 ID - ref32 ER - TY - STD TI - Rietveld CA, Medland SE, Derringer J, Yang J, Esko T, Martin NW, Westra HJ, Shakhbazov K, Abdellaoui A, Agrawal A et al. GWAS of 126,559 individuals identifies genetic variants associated with educational attainment. Science. 2013;340(6139):1467–71. ID - ref33 ER - TY - STD TI - Benyamin B, Pourcain B, Davis OS, Davies G, Hansell NK, Brion MJ, Kirkpatrick RM, Cents RA, Franic S, Miller MB et al. Childhood intelligence is heritable, highly polygenic and associated with FNBP1L. Mol Psychiatry. 2014;19(2):253–8. ID - ref34 ER - TY - STD TI - de Moor MH, Costa PT, Terracciano A, Krueger RF, de Geus EJ, Toshiko T, Penninx BW, Esko T, Madden PA, Derringer J et al. Meta-analysis of genome-wide association studies for personality. Mol Psychiatry. 2012;17(3):337–49. ID - ref35 ER - TY - STD TI - de Moor MH, van den Berg SM, Verweij KJ, Krueger RF, Luciano M, Arias Vasquez A, Matteson LK, Derringer J, Esko T, Amin N et al. Meta-analysis of genome-wide association studies for neuroticism, and the polygenic association with major depressive disorder. JAMA Psychiatry. 2015;72(7):642–50. ID - ref36 ER - TY - STD TI - van den Berg SM, de Moor MH, McGue M, Pettersson E, Terracciano A, Verweij KJ, Amin N, Derringer J, Esko T, van Grootheest G et al. Harmonization of neuroticism and extraversion phenotypes across inventories and cohorts in the Genetics of Personality Consortium: an application of Item Response Theory. Behav Genet. 2014;44(4):295–313. ID - ref37 ER -