Skip to main content

Table 1 GWAS information and SMR results for 28 complex traits and diseases

From: Predicting gene targets from integrative analyses of summary data from GWAS and eQTL studies for 28 human complex traits

Trait/Disease

N for quantitative traits or Ncases/Ncontrols

Number of genes (probes) GWS for the SMR test

Number of genes (probes) not rejected by the HEIDI test

Reference

Attention deficit and hyperactivity disorder (ADHD)

2787/2635

[22]

Alzheimer's disease (ALZ)

17,008/37,154

7 (8)

2 (2)

[23]

Autism spectrum disorder (ASD)

13,088/16,664

[24]

Bipolar disorder (BIP1)

7481/9250

1 (1)

1 (1)

[25]

Major depressive disorder (MDD)

9240/9519

[26]

Inflammatory bowel disease (IBD)

12,882/21,770

37 (40)

14 (14)

[19]

Crohn's disease (CD)

5956/14,927

29 (33)

11 (12)

[19]

Ulcerative colitis (UC)

6968/20,464

17 (17)

6 (6)

[19]

Coronary artery disease (CAD)

60,801/123,504

9 (9)

5 (5)

[27]

Diastolic blood pressure (DBP)

69,395

5 (5)

[28]

Systolic blood pressure (SBP)

69,395

4 (4)

[28]

High-density lipoproteins (HDL)

93,561

38 (43)

12 (13)

[29]

Low-density lipoproteins (LDL)

89,138

28 (31)

6 (7)

[29]

Total cholesterol (TC)

93,845

40 (43)

8 (9)

[29]

Triglycerides (TG)

90,263

22 (25)

2 (2)

[29]

Type-2 diabetes (T2D)

12,171/56,862

[30]

Fasting glucose (FGLUCOSE)

38,422

4 (5)

[31]

Fasting insulin (FINSULIN)

23,823

[31]

Cigarettes per day (CIGPERDAY)

38,181

2 (3)

1 (2)

[32]

Ever smoked (EVERSMOKED)

74,035

[32]

College completion (COLLEGE) [33]

95,427

1 (1)

1 (1)

[33]

Education attainment (EDUYEARS)

101,069

3 (3)

3 (3)

[33]

Intelligence quotient (IQ)

17,989

[34]

Agreeableness (AGREE)

17,375

[35]

Conscientiousness (CONS)

17,375

[35]

Extraversion (EXTRAVERT)

17,375

[35]

Neuroticism (NEUROTIC)

63,661

[36, 37]

Openness (OPEN)

17,375

[35]

Total

 

247 (271)

71 (77)

 
  1. Probe: a specific DNA sequence designed on a gene expression array to capture a transcript