Fig. 3
From: Cancer network activity associated with therapeutic response and synergism
Specific biological processes and high-centrality network nodes contribute to CNA-associated differences. a Tertile distributions of network nodes according to standardized centrality measure. The GO biological processes and REACTOME pathways significantly enriched (FDR < 5 %) in the tertile with the highest centrality are listed in the right panels. b Panels showing the distribution of PCCs for drugs that target CTKs or STKs, when the lowest, middle, or highest tertiles of centrality are active (i.e. nodes for the remaining tertiles are “deactivated” by assigning the average network centrality value). The empirical p values for the comparison of distributions are shown; distributions are only different when the highest tertile of centrality is active, as seen for the complete dataset. c Correlation between signaling entropy and CNA measures in the same cancer cell lines dataset