Fig. 1
From: VARPRISM: incorporating variant prioritization in tests of de novo mutation association
Power comparison between fitDNM, Poisson-all, Poisson-LGD, and VARPRISM. Left: Power benchmark using de novo mutations in ASD risk genes as damaging mutations. Right: Power benchmark using Human Gene Mutation Database (HGMD) variants as damaging mutations. The sample size is 5000 genomes and the number of trials is 1000. We set the statistical significance threshold at 5 × 10–4