Table 1 Type I error of VARPRISM in the null simulations (showing 95Â % CI in the bracket)
From: VARPRISM: incorporating variant prioritization in tests of de novo mutation association
| Â | Autism | HGMD | ||
|---|---|---|---|---|
|  | alpha = 0.05 | alpha = 0.01 | alpha = 0.05 | alpha = 0.01 |
VARPRISM | 0.0499 (0.0456–0.0545) | 0.0110 (0.0090–0.0133) | 0.0482 (0.0440–0.0527) | 0.0104 (0.0085–0.0126) |
fitDNM | 0.0510 (0.0468–0.0555) | 0.0088 (0.0070–0.0108) | 0.0470 (0.0429–0.0514) | 0.0096 (0.0078–0.0117) |
Poisson-all | 0.0219 (0.0191–0.0250) | 0.0077 (0.0061–0.0096) | 0.0213 (0.0185–0.0244) | 0.0075 (0.0059–0.0094) |
Poisson-LGD | 0.0265 (0.0234–0.0299) | 0.0018 (0.0011–0.0028) | 0.0240 (0.0211–0.0272) | 0.0025 (0.0016–0.0037) |