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Table 1 Type I error of VARPRISM in the null simulations (showing 95 % CI in the bracket)

From: VARPRISM: incorporating variant prioritization in tests of de novo mutation association

  Autism HGMD
  alpha = 0.05 alpha = 0.01 alpha = 0.05 alpha = 0.01
VARPRISM 0.0499 (0.0456–0.0545) 0.0110 (0.0090–0.0133) 0.0482 (0.0440–0.0527) 0.0104 (0.0085–0.0126)
fitDNM 0.0510 (0.0468–0.0555) 0.0088 (0.0070–0.0108) 0.0470 (0.0429–0.0514) 0.0096 (0.0078–0.0117)
Poisson-all 0.0219 (0.0191–0.0250) 0.0077 (0.0061–0.0096) 0.0213 (0.0185–0.0244) 0.0075 (0.0059–0.0094)
Poisson-LGD 0.0265 (0.0234–0.0299) 0.0018 (0.0011–0.0028) 0.0240 (0.0211–0.0272) 0.0025 (0.0016–0.0037)